Target Name: CD3 Complex (T Cell Receptor Complex)
NCBI ID: P8262
Other Name(s): TCR | T Cell Receptor Complex | CD3 antigen | T cell Receptor

CD3 Complex: A Drug Target for Cancer Treatment

The CD3 complex, also known as the T cell receptor complex or TCR, is a critical protein complex that plays a crucial role in the immune system. It is made up of several proteins that work together to identify and respond to foreign substances in the body, particularly viruses and cancer cells.

The CD3 complex is composed of the following proteins:

1. CD3: This is the protein that forms the core of the TCR complex. It is a type of transmembrane protein that contains a tyrosine kinase domain and a nucleotide-binding domain.
2. CD43: This protein is also a core member of the CD3 complex. It is a type of transmembrane protein that contains a tyrosine kinase domain and a nucleotide-binding domain.
3. CD81: This protein is also a core member of the CD3 complex. It is a cytoplasmic protein that contains a nucleotide-binding domain.
4. CD83: This protein is also a core member of the CD3 complex. It is a cytoplasmic protein that contains a nucleotide-binding domain.
5. PD-L1: This protein is a non-core member of the CD3 complex. It is a transmembrane protein that contains a nucleotide-binding domain and a C-type tyrosine kinase domain.

The CD3 complex is responsible for several important functions in the immune system, including:

1. Recognition of foreign substances: The CD3 complex is involved in the recognition of foreign substances, such as viruses and cancer cells, by the T cells. This is done by the presentation of the foreign substance on the major histocompatibility complex (MHC) class I molecules on the surface of the T cell.
2. Activation of the T cell: Once the CD3 complex recognizes a foreign substance, it activates the T cell by tyrosination, which is the process by which the tyrosine kinase domain on CD3 becomes activated and signals the T cell to mount an immune response.
3. Cellular responses: The CD3 complex is involved in the cellular responses that occur after the T cell is activated. This includes the production of IFN-纬, which is a cytokine that activates and coordinates the responses of T cells, as well as the production of other cytokines and enzymes.

Despite its critical role in the immune system, the CD3 complex is also a drug target and has been targeted by several anti-cancer drugs, including adoptive T cell transfer and DNA-based therapies.

One of the most promising strategies for targeting the CD3 complex is adoptive T cell transfer. This is a process in which immune cells, such as T cells, are adoptively transplanted into cancer cells to kill them. By targeting the CD3 complex, adoptive T cell transfer has the potential to be an effective cancer treatment.

Another approach for targeting the CD3 complex is DNA-based therapies. DNA-based therapies work by delivering small interfering RNA (siRNA) to cancer cells, which can disrupt the expression of genes that are critical for cancer cell growth and survival. By targeting the CD3 complex, DNA-based therapies have the potential to be an effective cancer treatment.

In conclusion, the CD3 complex is a critical protein complex that plays a crucial role in the immune system. It is involved in the recognition of foreign substances, the activation of the T cell, and the cellular responses that occur after the T cell is activated. The CD3 complex is also a drug target and has the potential to be an effective cancer treatment. Further research is needed to better understand the mechanisms of the CD3 complex and to develop more effective therapies for targeting it.

Protein Name: CD3 Complex (T Cell Receptor Complex)

More Common Targets

CD300A | CD300C | CD300E | CD300LB | CD300LD | CD300LD-AS1 | CD300LF | CD300LG | CD302 | CD320 | CD33 | CD34 | CD36 | CD37 | CD38 | CD3D | CD3E | CD3G | CD4 | CD40 | CD40LG | CD44 | CD44-DT | CD46 | CD47 | CD48 | CD5 | CD52 | CD53 | CD55 | CD58 | CD59 | CD5L | CD6 | CD63 | CD68 | CD69 | CD7 | CD70 | CD72 | CD74 | CD79A | CD79B | CD8 | CD80 | CD81 | CD81-AS1 | CD82 | CD83 | CD84 | CD86 | CD8A | CD8B | CD8B2 | CD9 | CD93 | CD96 | CD99 | CD99L2 | CD99P1 | CDA | CDADC1 | CDAN1 | CDC123 | CDC14A | CDC14B | CDC14C | CDC16 | CDC20 | CDC20-DT | CDC20B | CDC20P1 | CDC23 | CDC25A | CDC25B | CDC25C | CDC26 | CDC27 | CDC27P2 | CDC34 | CDC37 | CDC37L1 | CDC37P1 | CDC40 | CDC42 | CDC42BPA | CDC42BPB | CDC42BPG | CDC42EP1 | CDC42EP2 | CDC42EP3 | CDC42EP4 | CDC42EP5 | CDC42SE1 | CDC42SE2 | CDC45 | CDC5L | CDC5L complex | CDC6 | CDC7